Immunization With Herpes Simplex Virus Nanoparticles Targeting Both Attachment and Fusion Protect Against Infection
Dawid Maciorowski, Alexander C Vostal, Wei Bu, Isabella S. Pytel, Sophia Antonioli-Schmit, Jianghai Zhu, Forrest H. Hoyt, Haotian Lei, Guangping Liu, Kristen Kaiser, Richard Herbert, Kennichi Dowdell, John T. Schiller, Kening Wang, Mark R. Howarth, Jeffrey I. Cohen
This study develops HSV-2 nanoparticles targeting both gD and gH/gL, showing that combined immunization provides robust protection through complementary mechanisms beyond neutralization.
bioRxiv · Apr 29, 2026 · PreprintImmunology