A qualitative and quantitative framework for the characterization of protein-RNA interactions by cross-linking mass spectrometry (XL-MS)
Izabela Smok, Aurélie Zbinden, Johannes Osterroth, Jianning Jiang, Frédéric H.‐T. Allain, Jonathan Hall, Magdalini Polymenidou, Alexander Leitner
This paper introduces a XL-MS workflow combining DDA and PRM for quantitative characterization of protein-RNA interactions, applied to TDP-43 and FOX1 complexes.
bioRxiv · Oct 19, 2026 · PreprintBiophysics