Jonathan Hall

This paper introduces a XL-MS workflow combining DDA and PRM for quantitative characterization of protein-RNA interactions, applied to TDP-43 and FOX1 complexes.

The paper shows that SYBR Gold fluorescence is strongly influenced by guanosines in single-stranded nucleic acids, impacting its use in nucleic acid quantification.

This study identifies miRNA-29 targets and functions in skin repair using miRNA-CLIP and ASO, revealing roles in protein folding, RNA processing, and cell adhesion.

This study shows Enoxacin reduces HIV-1 replication by downregulating hsa-miR-132-3p in T-cells, suggesting potential for antiviral therapy through miRNA modulation.

This study determines the solution structure of DND1 bound to AU-rich RNA, revealing a novel tandem RRM-RNA recognition mechanism essential for mRNA regulation.

This study evaluates splice-switching oligonucleotides (SSOs) in a mouse model of Erythropoietic Protoporphyria, showing that an SSO with a cholesteryl group increases correctly spliced FECH transcript by 80% in bone marrow.

This study shows that covalently linking a DNA repair template to the CRISPR/Cas9 complex increases HDR efficiency 23-fold compared to NHEJ.