Ultra-sensitive FLORA-seq links cell-type-specific tRNAome dynamics to differentiation trajectories guiding therapeutic suppressor tRNA candidate selection
Hui Li, You-Jia Zhou, Zhen Zhang, Jianyang Ge, Zi-Ce Zhou, Wenyu Zhu, Xing-Yi Wu, Jiandi Wu, Pei-Yu Tian, Yawei Gao, Jianlong Sun, Ru‐Juan Liu
The paper introduces FLORA-seq to profile tRNAs and their modifications in low-input samples, revealing cell-type-specific dynamics and guiding suppressor tRNA candidate selection.
bioRxiv · Apr 15, 2026 · PreprintMolecular Biology