Bryan C. Dickinson

This study identifies METTL7A as a mechanosensitive methyltransferase that regulates internal m7G methylation in endothelial cells, protecting against atherosclerosis through stabilization of anti-inflammatory transcripts.

PANCS-Inhibitors rapidly selects molecules that directly disrupt pre-formed protein-protein interactions, demonstrating effectiveness against three oncogenic PPIs.

PANCS-spec-Binders rapidly identifies binders with defined specificity by combining selection and counterselection to target specific isoforms or epitopes.

This paper develops a human-based translational activator to restore protein expression in a Dravet syndrome mouse model, showing improved survivability and seizure threshold.

This study identifies APT1/LYPLA1 as a context-dependent vulnerability in triple-negative breast cancer by showing its role in regulating cell proliferation through de-S-acylation of cell-cycle and mitochondrial proteins.

The paper identifies target-specific fitness landscapes in protein-protein interactions and develops a supervised contrastive learning approach to predict binders.

This paper introduces PANCS-binders, an in vivo selection method for discovering protein binders, and demonstrates its ability to screen billions of variants against multiple targets in two days.

The paper introduces a strategy to enhance C>U RNA editors using IDR-derived domains, improving both on- and off-target editing efficiency.

The paper identifies a lncRNA, Gas5, involved in fear extinction by regulating RNA granule trafficking and clustering at synapses in mice.

This study uses hydrogen deuterium exchange mass spectrometry to show that Mcl-1's binding specificity arises from dynamic modes in its unbound state, distinct from Bcl-2.

This study shows that synaptic activity affects post-translational modifications of palmitoylating enzymes but not depalmitoylating enzymes in the hippocampus.

The paper identifies synapse-specific m6A RNA readers and their role in fear extinction memory consolidation through RNA immunoprecipitation and sequencing in mice.

CASowary predicts CRISPR-Cas13 guide RNA efficacy using machine learning and transcriptome data from HEK293 cells.

This paper reports structural and biochemical studies of SARS-CoV-2 papain-like protease and its complexes with inhibitors, showing their ability to inhibit enzyme activity and viral replication.