Insights into the AAV packaging mechanism: Cryo-EM Structure of the AAV2 Rep-Capsid Packaging Complex
Jason T. Kaelber, Vadim Barnakov, Jiayu Shen, Karen Hernandez, Harrison J. Tarbox, Areeba Khan, Carlos R. Escalante
This study determines the cryo-EM structure of the AAV2 Rep-capsid packaging complex, revealing how Rep proteins interact with the capsid and contribute to genome packaging.
bioRxiv · Dec 9, 2025 · PreprintBiochemistry