Nan Wang

Large-scale Perturbation of Systems Biology-Derived Genes Reveals Modifiers of HD-associated Transcriptomic Networks and Pathology

The paper uses genetic perturbations to identify modifiers of HD-associated transcriptomic networks and pathology in mice and patient-derived neurons.

Reconstructing a physiological state space via chronic jugular microdialysis in freely moving mice

The paper measures hundreds of amines and peptides in freely moving mice using microdialysis and mass spectrometry, revealing high-dimensional physiological dynamics and state transitions.

Single-cell copy number alteration signature analysis reveals masked patterns and potential biomarkers for cancer

This study analyzes CNA signatures in single-cell and bulk samples of hepatocellular carcinoma, revealing masked patterns and potential biomarkers for prognosis and treatment.

Genetic-Dependent Brain Signatures of Resilience: Interactions among Childhood Abuse, Genetic Risks and Brain Function

The paper identifies a genetic-dependent brain signature of resilience linked to childhood abuse and depression risk in girls, showing its predictive value for emotional disorders in adolescence and early adulthood.

Msh3 and Pms1 Set Neuronal CAG-repeat Migration Rate to Drive Selective Striatal and Cortical Pathogenesis in HD Mice

This study identifies Msh3 and Pms1 as genetic drivers of CAG-repeat migration in HD mice, leading to selective striatal and cortical pathogenesis.