Beyond single-slope Mendelian randomization: structural representation of genetic heterogeneity in joint effect space
Hongdong Hao, Dian Chen, Cheng Qian, Xuanyi Zhou, Hao Huang, Jiayu Zuo, Guanlin Wang, Xi Peng, Haixin Liu
This paper introduces MR-UBRA, a Bayesian framework for analyzing genetic heterogeneity in Mendelian randomization, showing it can resolve multi-component structures in causal effect space.
medRxiv · Mar 14, 2026 · PreprintGenetic & Genomic Medicine