Hao Huang

PA-SfM: Tracker-free freehand 3D photoacoustic imaging via differentiable acoustic radiation

PA-SfM enables tracker-free freehand 3D photoacoustic imaging with improved spatial coverage and reconstruction quality compared to traditional methods.

Charting neuroimaging-based head circumference and cranial shape across development

CranioTrace automates head circumference and cranial shape measurement from neuroimaging, enabling population growth modeling and identifying disease-related growth trajectory shifts.

The PMADS Project: A Longitudinal Multimodal Cohort Study to Understand Risk for Perinatal Mood and Anxiety Disorders

The PMADS Project tracks neurobiological and clinical changes in high-risk individuals across the perinatal period to identify biomarkers linking brain plasticity to PMADs risk.

Early-life stress alters chromatin modifications in VTA to prime stress sensitivity

This study shows early-life stress alters chromatin modifications in the VTA, increasing stress sensitivity through changes in histone dynamics and Setd7 activity.

Beyond single-slope Mendelian randomization: structural representation of genetic heterogeneity in joint effect space

This paper introduces MR-UBRA, a Bayesian framework for analyzing genetic heterogeneity in Mendelian randomization, showing it can resolve multi-component structures in causal effect space.

dGAMLSS: An exact, distributed algorithm to fit Generalized Additive Models for Location, Scale, and Shape for privacy-preserving population reference charts

The paper introduces dGAMLSS, a distributed algorithm for fitting GAMLSS models to construct population reference charts without sharing patient data.

Profiling brain morphology for autism spectrum disorder with two cross-culture large-scale consortia

This study identifies two ASD subgroups with distinct brain morphology using cross-cultural datasets, highlighting key brain regions associated with subgroup characteristics and autistic traits.

Engineered mitochondrial A-to-G editors with enhanced efficiency and targeting scope

This paper develops eTd-mtABEs, engineered mitochondrial A-to-G base editors with enhanced efficiency and targeting scope, enabling efficient generation of mtDNA disease models in rat embryos.

CTHRC1 is a new therapeutic target and serum diagnostic biomarker for aortic dissection

This paper identifies CTHRC1 as a therapeutic target and serum biomarker for aortic dissection, showing it regulates VSMC phenotype and aortic integrity via the ERK1/2 pathway.