Genetic & Genomic MedicinemedRxivPreprint
Beyond single-slope Mendelian randomization: structural representation of genetic heterogeneity in joint effect space
Hongdong Hao, Dian Chen, Cheng Qian…·Haixin Liu
This paper introduces MR-UBRA, a Bayesian framework for analyzing genetic heterogeneity in Mendelian randomization, showing it can resolve multi-component structures in causal effect space.
DOI 10.64898/2026.03.12.26348288