Guanlin Wang

This study identifies LIN28B as essential for fetal B-lymphopoiesis and KMT2A::AFF1 infant leukemia initiation, showing its role in promoting proliferation and leukemogenesis.

The paper develops a stem cell aging clock using single-cell transcriptomics to predict clinical outcomes in AML by measuring transcriptional age deviation.

This paper introduces MR-UBRA, a Bayesian framework for analyzing genetic heterogeneity in Mendelian randomization, showing it can resolve multi-component structures in causal effect space.

The paper introduces an optimized snRNA-seq workflow for metabolic tissues, emphasizing ambient RNA removal, doublet detection, and data integration to improve analysis accuracy.