Author

Hongdong Hao

Shanxi University of Traditional Chinese MedicineORCID 0009-0003-2017-0728Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetic & Genomic Medicine· 1 Genetics· 1

Signature Assays, Organisms & Methods

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Research Focus:benchmarking· 2 Research Focus:gene regulatory network inference· 2 Assay:GWAS summary statistics· 2 Approach:statistical model· 2 Organism:Arabidopsis· 1 Approach:Bayesian inference· 1 Research Focus:differential expression· 1 Organism:human· 1

Frequent Co-Authors

Dian Chen· 2 shared Cheng QianiD· 1 shared Guanlin WangiD· 1 shared Haixin LiuiD· 1 shared Hao Huang· 1 shared Hui Xue· 1 shared Jiayu Zuo· 1 shared Tianyu MengiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersGenetics

Dian Chen

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2 papers

Recent·Most cited

Detecting domain-level organization in genome-wide association study summary statistics using frequency-impact-reliability profiles

Hongdong Hao, Dian Chen, Xinyu Zhang, Hui Xue, Tianyu Meng

This paper introduces FIR-GWAS, a framework that reveals domain-level organization in GWAS summary statistics by analyzing frequency-impact-reliability profiles across multiple traits and species.

bioRxiv · Jul 6, 2026 · PreprintGenetics

Beyond single-slope Mendelian randomization: structural representation of genetic heterogeneity in joint effect space

Hongdong Hao, Dian Chen, Cheng Qian, Xuanyi Zhou, Hao Huang, Jiayu Zuo, Guanlin Wang, Xi Peng, Haixin Liu

This paper introduces MR-UBRA, a Bayesian framework for analyzing genetic heterogeneity in Mendelian randomization, showing it can resolve multi-component structures in causal effect space.

medRxiv · Mar 14, 2026 · PreprintGenetic & Genomic Medicine