Heterochronic parabiosis reprograms the mouse brain transcriptome by shifting aging signatures in multiple cell types
Methodios Ximerakis, Kristina M. Holton, Richard M. Giadone, Ceren Ozek, Monika Saxena, Samara Santiago, Xian Adiconis, Danielle Ashley Dionne, Lan Nguyễn, Kavya M. Shah, Jill M. Goldstein, Caterina Gasperini, Ioannis A. Gampierakis, Scott Lipnick, Sean Simmons, , Lee L. Rubin
This study uses single-cell transcriptomics to show that heterochronic parabiosis alters aging signatures in multiple brain cell types, with endothelial cells showing significant transcriptional changes.
Nature Aging · Mar 9, 2023Peer-reviewedNeuroscience