Kristina M. Holton

Combinatorial Modulation of Wnt, STAT3, TGF-β, and Tie2 Pathways Drives Brain Endothelial Cell-Like Differentiation from hiPSCs

The paper identifies signaling pathways that drive the differentiation of brain endothelial cells from hiPSCs in vitro.

Microbiome depletion rejuvenates the aging brain

The paper shows that depleting the gut microbiome in aged mice rejuvenates the brain by improving vascular density, myelination, neurogenesis, and reducing inflammation.

An induced pluripotent stem cell-based chemical genetic approach for studying spinal muscular atrophy

The paper uses a chemical genetic approach with induced pluripotent stem cells to screen for compounds affecting SMA neuronal gene expression, generating a queryable dataset of transcriptional profiles.

Coupling comprehensive pesticide-wide association study to iPSC dopaminergic screening identifies and classifies Parkinson-relevant pesticides

The paper combines epidemiological pesticide exposure data with iPSC-derived dopaminergic neuron screening to identify and classify pesticides linked to Parkinson's disease.

An automated high-content synaptic phenotyping platform in human neurons and astrocytes reveals a role for BET proteins in synapse assembly

The paper develops an automated high-content synaptic phenotyping platform in human neurons and astrocytes, identifying BET inhibitors as key regulators of synapse assembly.

Heterochronic parabiosis reprograms the mouse brain transcriptome by shifting aging signatures in multiple cell types

This study uses single-cell transcriptomics to show that heterochronic parabiosis alters aging signatures in multiple brain cell types, with endothelial cells showing significant transcriptional changes.

Creb5 establishes the competence for Prg4 expression in articular cartilage

This study identifies Creb5 as a transcription factor required for TGF-β and EGFR signaling to induce Prg4 expression in superficial zone articular chondrocytes.

Sphingosine 1-phosphate-regulated transcriptomes in heterogenous arterial and lymphatic endothelium of the aorta

The paper characterizes S1PR1-regulated transcriptomes in aortic endothelial cells, revealing distinct subtypes and signaling mechanisms in arterial and lymphatic endothelium.

Longitudinal Trajectory of Early Functional Recovery in Patients with First Episode Psychosis

The paper identifies distinct functional recovery trajectories in first episode psychosis patients using data-driven methods and explores associated risk factors.