Author

Caterina Gasperini

Harvard UniversityORCID 0000-0002-4197-7729Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Organism:mouse· 3 Research Focus:differential expression· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Approach:experimental assay· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

Kristina M. HoltoniD· 2 shared Lee L. RubiniD· 2 shared Richard M. GiadoneiD· 2 shared Alberto DiasproiD· 1 shared Amanda Lo VaniD· 1 shared Amy J. WagersiD· 1 shared Anna KiemiD· 1 shared Aviv RegeviD· 1 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersNeuroscience

Kristina M. HoltonORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Microbiome depletion rejuvenates the aging brain

Caterina Gasperini, Kristina M. Holton, Francesco Limone, Mahitha Juttu, Cristina C. DeMeo, Kristina Kekrtova, Sayalee Patankar, Kaylee M Wells, Richard M. Giadone, Laura Ben Driss, Guoqin Wei, Anna Kiem, Qiaohan Xu, Richard Lee, Martin Friedlander, , Lee L. Rubin

The paper shows that depleting the gut microbiome in aged mice rejuvenates the brain by improving vascular density, myelination, neurogenesis, and reducing inflammation.

bioRxiv · Feb 15, 2026 · PreprintNeuroscience

Heterochronic parabiosis reprograms the mouse brain transcriptome by shifting aging signatures in multiple cell types

Methodios Ximerakis, Kristina M. Holton, Richard M. Giadone, Ceren Ozek, Monika Saxena, Samara Santiago, Xian Adiconis, Danielle Ashley Dionne, Lan Nguyễn, Kavya M. Shah, Jill M. Goldstein, Caterina Gasperini, Ioannis A. Gampierakis, Scott Lipnick, Sean Simmons, , Lee L. Rubin

This study uses single-cell transcriptomics to show that heterochronic parabiosis alters aging signatures in multiple brain cell types, with endothelial cells showing significant transcriptional changes.

Nature Aging · Mar 9, 2023Peer-reviewedNeuroscience

The piRNA pathway sustains adult neurogenesis by repressing protein synthesis and cellular senescence

Caterina Gasperini, Kiril Tuntevski, Silvia Beatini, Roberta Pelizzoli, Amanda Lo Van, Damiano Mangoni, Rosa Maria Cossu, Giovanni Pascarella, Paolo Bianchini, Pascal Bielefeld, Margherita Scarpato, Meritxell Pons‐Espinal, Remo Sanges, Alberto Diaspro, Carlos Patricio Fitzsimons, , Davide De Pietri Tonelli

This study shows that the piRNA pathway is essential for adult neurogenesis by repressing protein synthesis and cellular senescence in mouse hippocampal neural progenitor cells.

EMBO Reports · Dec 6, 2022Peer-reviewedNeuroscience