Richard M. Giadone

This study shows disease-associated mutations can directionally alter epigenetic age in iPSC-derived organoids, providing a model to study aging and disease interactions.

The paper shows that depleting the gut microbiome in aged mice rejuvenates the brain by improving vascular density, myelination, neurogenesis, and reducing inflammation.

The paper uses a chemical genetic approach with induced pluripotent stem cells to screen for compounds affecting SMA neuronal gene expression, generating a queryable dataset of transcriptional profiles.

This paper develops a human iPSC-derived motor neuron-myogenic coculture platform to study NMJ innervation after axon injury and in SMA, showing blebbistatin enhances NMJ reinnervation and confirming reduced NMJ function in SMA patient-derived neurons.

The paper identifies early molecular and functional signatures in cardiac AL amyloidosis patients with abnormal GLS and reduced inflammatory markers despite no significant amyloid fibril deposition.

The paper establishes a resource of iPSCs from centenarians and their offspring to study human longevity and resilience.

The paper uses ER stressors in ALS patient-derived motor neurons to identify druggable targets that protect against degeneration.

This study identifies GSDME as a mediator of mitochondrial damage and axon loss in neurodegenerative diseases, showing its role in ALS and FTD models.

This study uses single-cell transcriptomics to show that heterochronic parabiosis alters aging signatures in multiple brain cell types, with endothelial cells showing significant transcriptional changes.