CRISPRi Screen Identifies a Novel Growth Suppressor lncRNA, INSTAR, in Human Monocytes
Christy Montano, Eric Malekos, Sergio Covarrubias, Sol J. Katzman, Lisa A. Sudek, Jillian Ward, Susan B Carpenter
The paper identifies INSTAR, a novel lncRNA, as a growth suppressor in human monocytes through a CRISPRi screen, showing it regulates SFMBT2 expression to control proliferation.
bioRxiv · Oct 30, 2025 · PreprintImmunology