Sol J. Katzman

This study shows that reduced Satb2 gene dosage in cortical projection neurons leads to chromatin and circuit defects, causing cognitive and sensory impairments in a mouse model of SATB2-associated syndrome.

The paper identifies INSTAR, a novel lncRNA, as a growth suppressor in human monocytes through a CRISPRi screen, showing it regulates SFMBT2 expression to control proliferation.

This study identifies IGF2BP3's role in modulating miRNA targeting in MLL-AF4 leukemia by competing with AGO2 for 3'-UTR binding, thereby reducing miR-181a-mediated repression of oncogenic mRNAs.

This study identifies a sperm-enriched tRFValCAC that regulates early embryonic mRNA splicing and preimplantation development through interactions with hnRNPAB.

This study investigates how the branchpoint-interacting stem loop (BSL) structure in U2 snRNA affects splicing efficiency and gene expression by altering branchpoint recognition and U2 snRNP biogenesis.

The paper uses a CRISPRi screen to identify lncRNAs critical for human monocyte viability, finding two lncRNAs that regulate proliferation and cell cycle genes.

This study shows that epididymis-specific RNase A family genes are essential for fertility and regulate small RNA processing in sperm.

The paper identifies and functionally characterizes lncRNAs involved in human monocyte-to-macrophage differentiation using RNA-seq and high-throughput screening.

The paper proposes a mechanism by which intron-lariat spliceosomes convert lariats into circular RNAs, suggesting a role in intron transposition.

The paper studies how different introns respond to splicing inhibitors in a humanized yeast strain, revealing intron-specific sensitivity and the impact of BP sequence variation.

The paper identifies cis-acting elements linking alternative splicing to translational control across primate species and shows sequence variation affects polyribosome association.

The paper identifies KIN17 and PRCC as factors involved in maintaining 5' and 3' splice site identity during pre-mRNA splicing in C. elegans through a genetic screen and mRNA sequencing analysis.

This study shows androgen signaling modulates canonical Wnt activity in prostate basal stem cells, maintaining their multipotency by suppressing Wnt-driven differentiation.

The paper identifies over 150 new spliced regions in yeast genomes, termed protointrons, which are not conserved and may represent early stages of intron evolution.

The paper investigates how HNRNPA1 influences U2AF2 RNA binding in vivo, showing it shifts U2AF2 to decoy splice site sequences and affects exon skipping.

The paper identifies human-specific NOTCH2NL genes linked to neurodevelopmental disorders and shows they affect cortical neurogenesis through Notch signaling.

The paper investigates how Quaking isoforms Qk5 and Qk6 regulate each other's expression through post-transcriptional mechanisms, balancing their functions in splicing and translation.