Sergio Covarrubias

CRISPRi Screen Identifies a Novel Growth Suppressor lncRNA, INSTAR, in Human Monocytes

The paper identifies INSTAR, a novel lncRNA, as a growth suppressor in human monocytes through a CRISPRi screen, showing it regulates SFMBT2 expression to control proliferation.

CRISPRi Screen Uncovers lncRNA Regulators of Human Monocyte Growth

The paper uses a CRISPRi screen to identify lncRNAs critical for human monocyte viability, finding two lncRNAs that regulate proliferation and cell cycle genes.

Human long noncoding RNA, VILMIR, is induced by major respiratory viral infections and modulates the host interferon response

This study identifies VILMIR, a novel lncRNA upregulated by respiratory viral infections and IFN-β, which modulates the host interferon response.

Identification and Functional Characterization of lncRNAs involved in Human Monocyte-to-Macrophage Differentiation

The paper identifies and functionally characterizes lncRNAs involved in human monocyte-to-macrophage differentiation using RNA-seq and high-throughput screening.

Tracing cellular heterogeneity in pooled genetic screens via multi-level barcoding

This paper introduces multi-level barcoding to address clonal heterogeneity in pooled genetic screens and demonstrates its ability to resolve cellular heterogeneity issues.

The transcriptionally permissive chromatin state of ES cells is acutely tuned totranslational output

The paper shows that translation directly regulates chromatin state and transcription in ES cells, with reduced translation causing rapid chromatin changes.