Cancer BiologybioRxivPreprint
A new genetically engineered transplant model of glioma recapitulates key phenotypes of low- and high-grade gliomas
Devlin Forsythe, Shannon J. Oliver, Adam Valkovic…·Melanie Jane McConnell
This paper develops genetically engineered mouse cell line models (GEM-CLeMs) of glioma that recapitulate key phenotypes of low- and high-grade gliomas, offering a more accurate model of the tumor microenvironment than existing cell lines.
DOI 10.1101/2025.10.29.685449