A new genetically engineered transplant model of glioma recapitulates key phenotypes of low- and high-grade gliomas
Devlin Forsythe, Shannon J. Oliver, Adam Valkovic, Danielle Lewthwaite, Germaine Uys, Brittany Koning, David Eccles, Laveniya Satgunaseelan, Ian F. Hermans, Saskia Freytag, Jim R Whittle, Sarah A. Best, Melanie Jane McConnell
This paper develops genetically engineered mouse cell line models (GEM-CLeMs) of glioma that recapitulate key phenotypes of low- and high-grade gliomas, offering a more accurate model of the tumor microenvironment than existing cell lines.
bioRxiv · Oct 29, 2025 · PreprintCancer Biology