David Eccles

This paper designs an mRNA vaccine with fused SARS-CoV-2 RBDs from different variants to elicit cross-reactive antibodies without extensive somatic hypermutation.

This paper develops genetically engineered mouse cell line models (GEM-CLeMs) of glioma that recapitulate key phenotypes of low- and high-grade gliomas, offering a more accurate model of the tumor microenvironment than existing cell lines.

This paper describes a portable genomics system for detecting plant viruses and pests in Sub-Saharan Africa using field-deployable devices.

The paper presents an open-source workflow for establishing MinION long-read sequencing in any laboratory, achieving >8.5 Gb of data with mean read length 13 kb and N50 26 kb.

The paper demonstrates de novo long-read genome assembly of Nippostrongylus brasiliensis using MinION data, revealing complex DNA repeats and haplotypic variants.

This paper applies bootstrap sub-sampling to GWAS data to improve the detection of true genetic associations in Type 1 Diabetes, resulting in a more informative 5-SNP signature set.