Melanie Jane McConnell

This paper develops genetically engineered mouse cell line models (GEM-CLeMs) of glioma that recapitulate key phenotypes of low- and high-grade gliomas, offering a more accurate model of the tumor microenvironment than existing cell lines.

This study shows that stressed astrocytes can restore mitochondrial function through fusion with mesenchymal stromal cells, as evidenced by mitochondrial DNA transfer and long-term functional recovery.