Independent Genetic Effects of Glucagon-like Peptide-1 Receptor Locus on Body Mass Index and Type 2 Diabetes
Chang Liu, Qin Hui, Gregorio V. Linchangco, Amonae Dabbs‐Brown, Jin J Zhou, Jacob Joseph, Peter D. Reaven, Mary K. Rhee, Luc Djoussé, Kelly Cho, J. Michael Gaziano, Peter W.F. Wilson, Lawrence S. Phillips, the VA Million Veteran Program, Yan V. Sun
This study identifies two independent BMI-associated variants at the GLP1R locus with distinct associations with T2D risk, suggesting heterogeneous genetic mechanisms.
medRxiv · Apr 13, 2026 · PreprintGenetic & Genomic Medicine