This study conducts an X-chromosome-wide association study to identify genetic signals for heart failure and its subtypes, finding novel loci and replicating some in UK Biobank.

medRxiv · Apr 23, 2026 · PreprintGenetic & Genomic Medicine

Independent Genetic Effects of Glucagon-like Peptide-1 Receptor Locus on Body Mass Index and Type 2 Diabetes

Chang Liu, Qin Hui, Gregorio V. Linchangco, Amonae Dabbs‐Brown, Jin J Zhou, Jacob Joseph, Peter D. Reaven, Mary K. Rhee, Luc Djoussé, Kelly Cho, J. Michael Gaziano, Peter W.F. Wilson, Lawrence S. Phillips, the VA Million Veteran Program, Yan V. Sun

This study identifies two independent BMI-associated variants at the GLP1R locus with distinct associations with T2D risk, suggesting heterogeneous genetic mechanisms.

medRxiv · Apr 13, 2026 · PreprintGenetic & Genomic Medicine

Correction for Collider Bias in the Genome-wide Association Study of Diabetes-Related Heart Failure due to Bidirectional Relationship between Heart Failure and Type 2 Diabetes

Yan V. Sun, Chang Liu, Qin Hui, Jin J. Zhou, J. Michael Gaziano, Peter W.F. Wilson, the Million Veteran Program, Jacob Joseph, Lawrence S. Phillips

This paper corrects collider bias in a GWAS of diabetes-related heart failure, identifying novel loci and showing bidirectional genetic associations between T2D and HF.

medRxiv · Sep 22, 2023 · PreprintGenetic & Genomic Medicine

Associations of inflammation-related proteome with demographic and clinical characteristics of people with HIV in South Africa

Junyu Chen, Qin Hui, Chang Liu, Jaysingh Brijkumar, Johnathan A. Edwards, Claudia E. Ordóñez, Matthew R. Dudgeon, Henry Sunpath, Selvan Pillay, Pravi Moodley, Daniel R. Kuritzkes, Mohamed Y. S. Moosa, Tooru Nemoto, Vincent C. Marconi, Yan V. Sun

The paper identifies inflammation-related proteins associated with age, sex, and CD4+ cell count in HIV-positive individuals in South Africa, highlighting potential links to chronic diseases.

PROTEOMICS - CLINICAL APPLICATIONS · Sep 6, 2023Peer-reviewedGenetic & Genomic Medicine

Genome-wide association analysis and Mendelian randomization proteomics identify novel protein biomarkers and drug targets for primary prevention of heart failure

Danielle Rasooly, Gina Marie Peloso, Alexandre C. Pereira, Hesam Dashti, Claudia Giambartolomei, Eleanor Wheeler, Nay Aung, Brian R. Ferolito, Maik Pietzner, Eric H. Farber‐Eger, Quinn Stanton Wells, Nicole Kosik, Liam Gaziano, Daniel C. Posner, A. Patrícia Bento, , Juan Pablo Casas

This study identifies novel genetic risk variants and potential drug targets for heart failure using GWAS and Mendelian randomization proteomics.

Nature Communications · Jul 10, 2023Peer-reviewedGenetic & Genomic Medicine

Genetic Architecture of Heart Failure with Preserved versus Reduced Ejection Fraction

Jacob Joseph, Chang Liu, Qin Hui, Krishna G. Aragam, Zeyuan Wang, BRIAN R. CHAREST, Jennifer E. Huffman, Jacob M. Keaton, Todd L. Edwards, Serkalem Demissie, Luc Djoussé, Juan Pablo Casas, J. Michael Gaziano, Kelly Cho, Peter W.F. Wilson, , Yan V. Sun

This study compares the genetic architecture of heart failure with preserved ejection fraction (HFpEF) and reduced ejection fraction (HFrEF), finding distinct genetic associations and highlighting HFpEF's heterogeneity.

Nature Communications · Dec 14, 2022Peer-reviewedGenetic & Genomic Medicine