Author

Luc Djoussé

Brigham and Women's HospitalORCID 0000-0002-9902-3047Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:GWAS summary statistics· 4 Organism:human· 4 Approach:statistical model· 4 Research Focus:GWAS / association mapping· 2 Research Focus:fine-mapping· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

J. Michael GazianoiD· 4 shared Kelly ChoiD· 3 shared Peter W.F. WilsoniD· 3 shared Qin HuiiD· 3 shared Yan V. SuniD· 3 shared Chang LiuiD· 2 shared Gregorio V. LinchangcoiD· 2 shared Jacob JosephiD· 2 shared

Activity by Year

2022-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 44 mutual co-author links

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4 shared papersGenetic & Genomic Medicine

J. Michael GazianoORCID

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4 papers

Recent·Most cited

Independent Genetic Effects of Glucagon-like Peptide-1 Receptor Locus on Body Mass Index and Type 2 Diabetes

Chang Liu, Qin Hui, Gregorio V. Linchangco, Amonae Dabbs‐Brown, Jin J Zhou, Jacob Joseph, Peter D. Reaven, Mary K. Rhee, Luc Djoussé, Kelly Cho, J. Michael Gaziano, Peter W.F. Wilson, Lawrence S. Phillips, the VA Million Veteran Program, Yan V. Sun

This study identifies two independent BMI-associated variants at the GLP1R locus with distinct associations with T2D risk, suggesting heterogeneous genetic mechanisms.

medRxiv · Apr 13, 2026 · PreprintGenetic & Genomic Medicine

Genome-wide association study provides novel insight into the genetic architecture of severe obesity.

Mohanraj Krishnan, Mohammad Yaser Anwar, Anne E. Justice, Geetha Chittoor, Hung‐Hsin Chen, Rashedeh Roshani, Alyssa Scartozzi, Rachel R. Dickerson, Roelof A. J. Smit, Michael H Preuss, Nathalie Chami, Benjamin S Hadad, Esteban Juan Parra, Miguel Cruz, Qin Hui, , Mariaelisa Graff

This study identifies novel genetic signals associated with severe obesity through GWAS and shows strong genetic overlap with BMI, highlighting shared comorbidities and lifestyle interactions.

PLoS Genetics · Sep 12, 2025Peer-reviewedGenetic & Genomic Medicine

A contextual genomic perspective on physical activity and its relationship to health, well-being and illness

Marco Galimberti, Daniel F. Levey, Joseph D. Deak, Keyrun Adhikari, Cassie M. Overstreet, Priya Dhamija Gupta, Rachana Nitin, Hang Zhou, Nicole J. Lake, Kelly M. Harrington, Luc Djoussé, Lea Karatheodoris Davis, VA Million Veteran Program, J. Michael Gaziano, Murray B. Stein, Joel E. Gelernter

This study investigates the genetic basis of physical activity across different contexts and finds that leisure-time activity has distinct genetic influences and protective health effects.

Nature Genetics · Jul 21, 2025Peer-reviewedGenetic & Genomic Medicine

Genetic Architecture of Heart Failure with Preserved versus Reduced Ejection Fraction

Jacob Joseph, Chang Liu, Qin Hui, Krishna G. Aragam, Zeyuan Wang, BRIAN R. CHAREST, Jennifer E. Huffman, Jacob M. Keaton, Todd L. Edwards, Serkalem Demissie, Luc Djoussé, Juan Pablo Casas, J. Michael Gaziano, Kelly Cho, Peter W.F. Wilson, , Yan V. Sun

This study compares the genetic architecture of heart failure with preserved ejection fraction (HFpEF) and reduced ejection fraction (HFrEF), finding distinct genetic associations and highlighting HFpEF's heterogeneity.

Nature Communications · Dec 14, 2022Peer-reviewedGenetic & Genomic Medicine