Jacob Joseph

This study conducts an X-chromosome-wide association study to identify genetic signals for heart failure and its subtypes, finding novel loci and replicating some in UK Biobank.

This study identifies two independent BMI-associated variants at the GLP1R locus with distinct associations with T2D risk, suggesting heterogeneous genetic mechanisms.

Population-stratified GWAS of 2,068 traits in 635,969 Million Veteran Program participants, 29% genetically non-European, yields 98,485 associations and 57,601 fine-mapped signals with largely shared cross-population architecture.

This paper corrects collider bias in a GWAS of diabetes-related heart failure, identifying novel loci and showing bidirectional genetic associations between T2D and HF.

This study identifies novel genetic risk variants and potential drug targets for heart failure using GWAS and Mendelian randomization proteomics.

This study compares the genetic architecture of heart failure with preserved ejection fraction (HFpEF) and reduced ejection fraction (HFrEF), finding distinct genetic associations and highlighting HFpEF's heterogeneity.

This study identifies a significant association between the V122I TTR variant and polyneuropathy in Black individuals, highlighting increased risk of hATTR amyloidosis manifestations.