Lawrence S. Phillips

This study identifies genetic loci associated with diabetic peripheral neuropathy, implicating serine biosynthesis in disease susceptibility through convergent evidence from common and rare variants.

This study conducts an X-chromosome-wide association study to identify genetic signals for heart failure and its subtypes, finding novel loci and replicating some in UK Biobank.

This study identifies two independent BMI-associated variants at the GLP1R locus with distinct associations with T2D risk, suggesting heterogeneous genetic mechanisms.

The paper develops a clinical algorithm to identify individuals with G6PD p.Val68Met variant at risk for diabetes undertreatment using routine lab measurements.

This paper corrects collider bias in a GWAS of diabetes-related heart failure, identifying novel loci and showing bidirectional genetic associations between T2D and HF.

This study identifies novel genetic risk variants and potential drug targets for heart failure using GWAS and Mendelian randomization proteomics.

This study compares the genetic architecture of heart failure with preserved ejection fraction (HFpEF) and reduced ejection fraction (HFrEF), finding distinct genetic associations and highlighting HFpEF's heterogeneity.

This study conducts a trans-ancestry GWAS using chronic ALT elevation as a proxy for NAFLD, identifies 77 significant loci, and validates 17 SNPs with histology and imaging data, revealing genetic links to metabolic and inflammatory traits.

Multi-ethnic type 2 diabetes (T2D) meta-analysis of 228,499 cases and 1,178,783 controls finds 318 previously unreported loci, 804 expression-colocalized genes, and 13 SNP-by-T2D vascular-outcome interactions.