Permissive and instructive Hox codes govern limb positioning
Y X Wang, Maik Hintze, Jinbao Wang, Hengxun Tao, Patrick Petzsch, Karl Köhrer, Longfei Cheng, Peng Zhou, Jianlin Wang, Zhaofu Liao, Xufeng Qi, Dongqing Cai, Thomas Bartolomaeus, Karl Schilling, Jörg Wilting, , Ruijin Huang
This study identifies Hox4/5 and Hox6/7 genes' roles in forelimb positioning through loss- and gain-of-function experiments in chick embryos, showing Hox4/5 provide permissive cues and Hox6/7 determine limb position.
eLife · Mar 20, 2026Peer-reviewedDevelopmental Biology