Chemical screens in aging-relevant human motor neurons identify MAP4Ks as therapeutic targets for amyotrophic lateral sclerosis
Menglu Liu, Shuaipeng Ma, Wenjiao Tai, Xiaoling Zhong, Haoqi Ni, Yuhua Zou, Jingcheng wang, Chun‐Li Zhang
The paper identifies MAP4Ks as therapeutic targets for ALS by screening chemical compounds in human motor neurons and shows a lead compound improves neuron survival and function.
bioRxiv · Apr 24, 2023 · PreprintNeuroscience