Chun‐Li Zhang

This study directly reprograms human monocytes into ipRGC-like neurons and identifies factors that enable this conversion.

This study investigates how dysregulated Lamin B1 in DYT1 dystonia affects nuclear structure and disrupts 14-3-3 proteins, linking nuclear deformation to neuronal dysfunction.

This study shows that SOX2 phosphorylation and the PRKDC-dependent NHEJ pathway are essential for in vivo glia-to-neuron reprogramming, with p53 knockdown restoring reprogramming in PRKDC-deficient mice.

This paper identifies Atto 643 carboxy as a highly specific fluorescent dye for astrocyte labeling with minimal oligodendrocyte cross-reactivity and improved specificity compared to SR101.

This study quantifies persistent postural and motor deficits after spinal cord injury in mice using unbiased, high-speed video tracking and machine learning.

This study shows that reprogramming NG2 glia with SOX2 improves bladder function in a mouse model of spinal cord injury by promoting neurogenesis and reducing glial scarring.

The paper shows that distinct alpha-synuclein strains from Parkinson's disease patient tissues induce different inclusion pathologies in a biosensor cell model.

This paper identifies a short human IBA1 promoter that enables specific targeting of microglia using AAV vectors, achieving up to 95% microglia transduction.

This study shows that reprogramming NG2 glia after spinal cord injury leads to axonal regeneration and improved function.

The paper identifies MAP4Ks as therapeutic targets for ALS by screening chemical compounds in human motor neurons and shows a lead compound improves neuron survival and function.

The paper shows that NEUROD1-induced neurons in the adult mouse brain originate from endogenous neurons, not astrocytes, highlighting the need for rigorous lineage tracing in reprogramming studies.

This study uses human neurons to model DYT1 dystonia, revealing LMNB1 dysregulation as a key factor in disease pathology.