BaCas12a3 represents a new subtype of type V CRISPR effector with collateral activity toward tRNA
Shiqi Ji, Xin Li, Chengwei Wu, Jinshan Guo, Ruyi Zheng, Jingwen Kong, Lei Du, Qunxin She
The paper identifies BaCas12a3 as a new type V CRISPR effector that inhibits growth through tRNA cleavage without causing DNA damage.
bioRxiv · Jan 16, 2026 · PreprintMolecular Biology