Lei Du

This paper engineers terminal deoxynucleotidyl transferase (TdT) to improve enzymatic DNA synthesis efficiency and scalability.

The paper identifies BaCas12a3 as a new type V CRISPR effector that inhibits growth through tRNA cleavage without causing DNA damage.

This paper identifies the enzymatic mechanism for forming the gamma-thiolactone ring in thiolactomycin biosynthesis, revealing the roles of TlnCCy and TlnA.