Xin Li

The paper identifies BaCas12a3 as a new type V CRISPR effector that inhibits growth through tRNA cleavage without causing DNA damage.

This paper develops a streamlined prime editing system for Escherichia coli Nissle 1917, achieving high editing efficiencies and reduced off-target effects for DNA deletion, insertion, and substitution.

This paper introduces XSTART, a PAM-independent base editing system for universal gene inactivation in bacteria, achieving near 100% efficiency but with off-target events.

This paper presents a CRISPR-Cas-based system called VADER for degrading antibiotic resistance genes (ARGs) in environmental biotechnology, achieving 100% ARG elimination in a prototype reactor.

This paper develops a base-editing tool for Synechococcus elongatus to enable precise genome modifications, enhancing glycogen content through multiplex editing.