Targeting THOC2-Mediated mRNA Export Induces PARP Inhibitor Vulnerability in DNA Repair-Competent Hepatocellular Carcinoma
Xinli Li, Songpeng Yang, Mengxin Zhang, Zhaoyu Guo, Yuxing Wang, Yanru Meng, Yuanping Liu, Hu Zhang, Kaikun Xu, Xiuyuan Zhang, Yuanjun Zhai, Jingzhuo Jin, Fuchu He, Chunyan Tian, Aihua Sun
This study identifies THOC2 as a regulator of DNA repair and growth in HCC, showing that targeting THOC2 enhances PARPi efficacy by disrupting mRNA export of DDR genes.
International Journal of Biological Sciences · Jun 10, 2026Peer-reviewedCancer Biology