The novel role of Kallistatin in linking metabolic syndromes and cognitive memory deterioration by inducing amyloid-β plaques accumulation and tau protein hyperphosphorylation
Weiwei Qi, Yanlan Long, Ziming Li, Zhen Zhao, Jinhui Shi, Wanting Xie, Laijian Wang, Yandan Tan, Ti Zhou, Minting Liang, Ping Jiang, Bin Jiang, Xia Yang, Guoquan Gao
This paper identifies Kallistatin's role in linking metabolic syndromes to cognitive decline by promoting amyloid-β plaques and tau hyperphosphorylation through Notch1 and GSK-3β pathways, and suggests fenofibrate as a potential treatment.
eLife · Aug 5, 2025Peer-reviewedNeuroscience