Targeting the ITGA3B1 Complex with A Novel Antibody-Drug Conjugate for Metastatic Bladder Cancer
Hyeryeon Jung, Junghyeon Lee, Eunhee G. Kim, Jinsung Ahn, Michael C. Haffner, Peter S. Nelson, Kwang Pyo Kim, John K. Lee, Eugene C. Yi, Kristine M. Kim
The paper identifies ITGA3B1 as a therapeutic target for metastatic bladder cancer using a phenotypic screening strategy and develops an ADC targeting this integrin complex, showing antitumor efficacy in preclinical models.
bioRxiv · Apr 6, 2025 · PreprintSynthetic Biology