SynNotch receptors for visualizing immunoreceptor force transmission and downstream signaling in vivo
Menglan Li, Jintian Lyu, Kaitao Li, Ameya Dravid, Deepali Balasubramani, Amir Hossein Kazemipour Ashkezari, Hyun-Kyu Choi, Gabriel A. Kwong, Ankur K. Singh, Cheng Zhu
This study develops SynNotch reporters to visualize force transmission and downstream signaling in immunoreceptors in vivo, showing force acts as a co-stimulus for CD40 and TCR signaling.
Advanced Science · Aug 25, 2026Peer-reviewedBioengineering