Endothelial ANGPT2 insufficiency impairs retinal vascularization with ROP-like neovascular tufts
Zhiliang Sun, Kai Ding, Taotao Li, Jinting Zhang, Xin Shen, Xiwen Jia, Xiao Li, Xudong Cao, Beibei Xu, Peirong Lu, Yulong He
This study shows that endothelial ANGPT2 deficiency causes retinal vascular defects similar to retinopathy of prematurity, with impaired tip cell invasion and hypoxia-driven changes.
bioRxiv · Aug 19, 2026 · PreprintDevelopmental Biology