Yulong He

Specification of bone marrow sinusoids requires TIE2-mediated positive feedback involving COUPTFII and VEGFR3

This study identifies TIE2-mediated positive feedback involving COUPTFII and VEGFR3 as essential for bone marrow sinusoid specification.

Endocardial TIE1 synergizes with TIE2 to regulate the atrial internal muscular network assembly

This study shows TIE1 and TIE2 work together in atrial development, with TIE1 specifically needed for atrial muscular network formation.

Endothelial ANGPT2 insufficiency impairs retinal vascularization with ROP-like neovascular tufts

This study shows that endothelial ANGPT2 deficiency causes retinal vascular defects similar to retinopathy of prematurity, with impaired tip cell invasion and hypoxia-driven changes.

Lymphatics unload VEGFR3 in response to the alteration of VEGFR2-mediated transcriptional programs

This study shows that VEGFR2 is essential for maintaining lymphatic endothelial identity and its loss alters transcriptional programs, reducing VEGFR3-mediated lymphangiogenesis.

Endothelial TIE1 restricts angiogenic sprouting to coordinate vein assembly in synergy with its homologue TIE2

This study investigates the role of TIE1 and its interaction with TIE2 in venous development, finding that TIE1 restricts angiogenic sprouting to coordinate vein formation.

Angiocrine FSTL1 insufficiency leads to atrial and vein wall fibrosis via SMAD3 activation

This study shows that loss of endothelial FSTL1 causes atrial and vein wall fibrosis through SMAD3 activation, leading to heart failure.