Xiao Li

Specification of bone marrow sinusoids requires TIE2-mediated positive feedback involving COUPTFII and VEGFR3

This study identifies TIE2-mediated positive feedback involving COUPTFII and VEGFR3 as essential for bone marrow sinusoid specification.

Susceptibility and cellular responses of COPD airway epithelium to cigarette smoke in stem cell-derived ALI models

This study compares the effects of high-tar and low-tar cigarette smoke on COPD airway epithelium using stem cell-derived ALI models, finding stronger responses to high-tar smoke across multiple molecular dimensions.

Endothelial ANGPT2 insufficiency impairs retinal vascularization with ROP-like neovascular tufts

This study shows that endothelial ANGPT2 deficiency causes retinal vascular defects similar to retinopathy of prematurity, with impaired tip cell invasion and hypoxia-driven changes.

Glutamine-Dependent Biosynthetic Pathways Fuel Autoreactive T and B Cells in Foxp3 Deficiency-mediated Disease

This study shows glutamine supports autoimmune disease in Foxp3 deficiency by fueling biosynthetic pathways in T and B cells, with distinct roles in cytokine production and autoantibody formation.

WattmaMod enables high-resolution and extensible RNA modification profiling for nanopore direct RNA sequencing

WattmaMod detects multiple RNA modifications from nanopore sequencing data using deep learning, achieving high accuracy and extending to low-resource modifications.

Longitudinal analysis of bacterial community dynamics in normal hospital ward following patient occupancy

This study analyzes bacterial community dynamics in a hospital ward after patient occupancy, showing increased alpha diversity on some surfaces and reduced diversity on others, with patient contact significantly influencing microbial composition.

Neural Timescale of Adolescents Major Depressive Disorder

This study identifies altered neural timescales in adolescents with major depressive disorder, linking them to clinical symptoms and neurobiological mechanisms.

Exploring the phenotypic consequences of tissue specific gene expression variation inferred from GWAS summary statistics

The paper develops S-PrediXcan to compute gene expression associations from GWAS summary data and applies it to 44 GTEx tissues and 100+ phenotypes, finding tissue-specific effects and colocalized associations.

Cholecystokinin release triggered by presynaptic NMDA receptors produces LTP and sound-sound associative memory formation

Presynaptic NMDA receptors control CCK release from entorhinal neurons, enabling neocortical LTP and sound-sound associative memory.

Colocalization of GWAS and eQTL Signals Detects Target Genes

This paper introduces eCAVIAR, a method to compute colocalization posterior probability between GWAS and eQTL signals to identify target genes and tissues for complex traits.

Distant regulatory effects of genetic variation in multiple human tissues

The paper identifies trans-eQTLs in multiple human tissues and shows their tissue-specific effects and association with disease.

Local genetic effects on gene expression across 44 human tissues

This study identifies cis-eQTLs across 44 human tissues using GTEx data, showing 88% of genes have cis-eQTLs and demonstrating their utility in understanding complex trait etiology.