PTBP1 is upregulated by Zika virus infection via HIF-1alpha signal and hijacks NS1 protein to induce NS1 degradation to restrain viral replication
Menglan Rao, Yue Kong, Shuang Liu, Zicong Chen, Jiuxiu Lin, Yicong Liang, Zhiwei Lei, Zhen Luo
This study identifies that ZIKV upregulates PTBP1 via HIF-1alpha, which then binds NS1 to promote its degradation, thereby inhibiting viral replication.
Journal of Virology · Apr 27, 2026Peer-reviewedMicrobiology