Diminished Immune Cell Adhesion in Hypoimmune ICAM-1 Knockout Pluripotent Stem Cells
Sayandeep Saha, W. John Haynes, Jiwon Seo, Natalia M. Del Rio, Elizabeth E. Young, Jue Zhang, Alexis M. Holm, Mireya Pimentel, Lauryn E. Flannagan, Liupei Huang, Wesley Blashka, Lydia Murphy, Merrick J. Scholz, Abigale Henrichs, Jayalaxmi Suresh Babu, , Matthew E. Brown
This paper identifies ICAM-1 as a novel hypoimmune target in human pluripotent stem cells, showing that its knock-out reduces immune cell adhesion and enhances graft survival.
Nature Communications · Aug 12, 2025Peer-reviewedImmunology