Glucose hypometabolism and hyperphosphorylated Tau synergistically drive neuronal necroptosis
Xiaoshi Chen, Sixuan Li, Antonia Neubauer, Xiang Li, Wei Mao, Matthias Brendel, Jixuan Liu, Mengmeng Zhang, Chongzhe Yang, 许瑞胜, Jianping Liu, Bing Shan, Junying Yuan, Cong Liu, Jochen Wolfgang Herms, Chengyu Zou
This study shows that glucose hypometabolism and hyperphosphorylated Tau work together to cause neuronal death through necroptosis in a mouse model.
Neuron · Apr 22, 2026Peer-reviewedNeuroscience