Jochen Wolfgang Herms

The paper identifies axonal branch points of parvalbumin interneurons as focal sites of Tau-induced degeneration in both mouse and human tauopathy.

This paper identifies molecular progression trajectories in PSP by integrating snATACseq and snRNAseq data with tau pathology, revealing cell-type-specific transcriptional changes and glial reactivity.

The paper investigates how ischemic injury affects microglial response to Aβ pathology, finding a protective microglial phenotype that promotes benign Aβ plaque formation.

This study shows that glucose hypometabolism and hyperphosphorylated Tau work together to cause neuronal death through necroptosis in a mouse model.

This paper develops a 3D cortical brain tissue model with mature microglia that recapitulates Alzheimer's disease hallmarks and enables study of microglia phenotypes.

This study identifies distinct TAF15 amyloid filament structures in different FTLD-FET subtypes, leading to the renaming of the disease group as FTLD-TAF15.

GluTrooper is a mouse line for whole-brain glutamate imaging with long-lasting sensor expression and multimodal imaging capabilities.

This study identifies genetic risk factors for FTLD-TDP subtypes using whole-genome sequencing and meta-analysis across multiple cohorts.

This study shows that alpha-Synuclein co-pathology in Alzheimer's Disease increases tau levels, linking AD and Parkinson's Disease pathogenesis.

This study shows that CX3CR1 deficiency enhances microglial migration towards brain injury, suggesting it as a potential therapeutic target for CNS injuries.

This study identifies six genetic loci associated with progressive supranuclear palsy, including a novel locus, and links them to oligodendrocytic dysfunction and C4A expression.

This study shows that neuronal and oligodendroglial tau, but not astroglial tau, contribute to tau-PET signals in 4-repeat tauopathies.

The paper identifies cellular sources of PET signals in glioblastoma by combining radiotracer uptake with 3D-histology and proteomics, showing tumor cells mainly contribute to TSPO enrichment while TAMs have specific PET targets.

This study shows that extracellular alpha-synuclein toxicity in Parkinson's disease is independent of intracellular alpha-synuclein and linked to mitochondrial dysfunction.

This study shows that chronic PPARγ agonist treatment increases amyloid-beta fibrillarity but improves cognition and synaptic density in mouse models.

This study shows that microbiota-derived short chain fatty acids (SCFA) increase Aβ plaque deposition in Alzheimer's disease by promoting microglial activation and ApoE upregulation.

This study shows that pre-therapeutic microglia activation and sex predict the response to chronic immunomodulation in AD mouse models using TSPO-PET.

This study shows that injecting alpha-synuclein fibrils into the striatum of mice leads to altered cortical neuron function and reduced inhibitory cells in the somatosensory cortex.

This study identifies proteomic changes in microglia during Alzheimer's disease progression in mouse models, showing fibrillar Aβ drives microglial dysfunction.

The paper investigates long-term neuronal activity dynamics in Alzheimer’s disease using calcium imaging in transgenic mice, finding stable aberrant activity patterns and a progressive gain of activity in certain neurons.