Matthias Brendel

Glucose hypometabolism and hyperphosphorylated Tau synergistically drive neuronal necroptosis

This study shows that glucose hypometabolism and hyperphosphorylated Tau work together to cause neuronal death through necroptosis in a mouse model.

TREM2 expression level is critical for microglial state, metabolic capacity and efficacy of TREM2 agonism

This study investigates how TREM2 expression levels affect microglial function, metabolism, and response to TREM2 agonists in a mouse model of Alzheimer's disease.

DISCO-seq: 3D single-cell transcriptomics of intact biological systems

DISCO-seq enables 3D single-cell transcriptomics of whole tissues and organisms by combining tissue-clearing chemistry with imaging and transcriptomic profiling.

Limitations of the radiotheranostic concept in neuroendocrine tumors due to lineage-dependent somatostatin receptor expression on hematopoietic stem and progenitor cells

This paper shows that hematopoietic stem and progenitor cells express somatostatin receptors, leading to unexpected toxicity from radiopharmaceuticals used in neuroendocrine tumors.

Deciphering sources of PET signals in the tumor microenvironment of glioblastoma at cellular resolution

The paper identifies cellular sources of PET signals in glioblastoma by combining radiotracer uptake with 3D-histology and proteomics, showing tumor cells mainly contribute to TSPO enrichment while TAMs have specific PET targets.

Chronic PPARγ Stimulation Shifts Amyloidosis to Higher Fibrillarity but Improves Cognition

This study shows that chronic PPARγ agonist treatment increases amyloid-beta fibrillarity but improves cognition and synaptic density in mouse models.

Loss of TREM2 reduces hyperactivation of progranulin deficient microglia but not lysosomal pathology

This study shows that TREM2 deficiency reduces microglial hyperactivation in GRN-deficient models but does not rescue lysosomal dysfunction or neurodegeneration biomarkers.

Pre-therapeutic Microglia Activation and Sex Determine Therapy Effects of Chronic Immunomodulation

This study shows that pre-therapeutic microglia activation and sex predict the response to chronic immunomodulation in AD mouse models using TSPO-PET.