Sixuan Li

This study shows that glucose hypometabolism and hyperphosphorylated Tau work together to cause neuronal death through necroptosis in a mouse model.

This paper introduces a crosslinking method to improve mRNA LNP stability and delivery efficiency, showing enhanced structural integrity and transfection performance in vitro and in vivo.

This study identifies the causes of payload heterogeneity in lipid nanoparticles and proposes methods to improve RNA distribution uniformity.

This paper develops a method to create high-concentration, shelf-stable DNA transfection particles for AAV production, achieving tenfold higher pDNA concentration and reduced dosing volume.