Claudin-12 deficiency causes nerve barrier breakdown, mechanical hypersensitivity and painful neuropathy
Jeremy Tsung-Chieh Chen, Xiawei Hu, Kathrin Doppler, Olga Breitkreuz-Korff, Isabel U. C. Otto, Joachim Schwabe, Ann‐Kristin Reinhold, Dorothee Günzel, Sophie Dithmer, Mohammed K. Hankir, Petra Fallier‐Becker, Lars Winkler, Rosel Blasig, Claudia Sommer, Alexander Brack, , Heike Lydia Rittner
This study identifies claudin-12's role in maintaining myelin and blood-nerve barriers, showing its deficiency causes mechanical hypersensitivity and painful neuropathy in male mice.
bioRxiv · Nov 26, 2019 · PreprintNeuroscience