Claudia Sommer

Multi-omic characterization of human sural nerves acrosspolyneuropathies

The paper integrates single nuclei transcriptomics and spatial transcriptomics of human peripheral nerves to identify novel cell markers, reveal pan-nerve disease characteristics, and demonstrate potential for unbiased diagnostic classification.

Neuropathic pain and distinct CASPR2 autoantibody IgG subclasses drive neuronal hyperexcitability

The paper investigates how CASPR2 autoantibody subclasses, particularly IgG4, affect neuronal excitability and potassium channel function in patients with neuropathic pain.

TAM receptors mediate the Fpr2-driven pain resolution and fibrinolysis after nerve injury

This study identifies the Fpr2-Cd206-TAM receptor axis as a target for pain resolution and fibrinolysis after nerve injury by resealing capillary barriers.

Neuronal toxicity and recovery from early bortezomib-induced neuropathy: targeting the blood nerve barrier but not the dorsal root ganglion

This study investigates bortezomib-induced neuropathy in rats and patients, showing that early toxicity targets the blood nerve barrier, which can recover through upregulation of netrin-1.

Claudin-12 deficiency causes nerve barrier breakdown, mechanical hypersensitivity and painful neuropathy

This study identifies claudin-12's role in maintaining myelin and blood-nerve barriers, showing its deficiency causes mechanical hypersensitivity and painful neuropathy in male mice.