Margaret A. Goodell

This study shows that nucleolar phase separation adapts to cellular energy levels, affecting rRNA transport and ribosome biogenesis.

This study shows that mutant NPM1 forms nuclear condensates called C-bodies, which are essential for leukemic gene expression and cell survival, and identifies them as potential therapeutic targets.

This study examines the long-term effects of chemotherapy on normal blood cells by analyzing mutation burdens and cell population structure in treated individuals.

This study examines how chemotherapy affects clonal diversity and mutation patterns in hematopoietic stem cells, finding that melphalan increases mutational burden and promotes clonal aging, potentially leading to therapy-related myeloid neoplasms.

This study identifies USP11 and SUMOylation as critical for maintaining DNMT3A stability and function, offering potential therapeutic strategies for diseases linked to DNMT3A instability.

This study examines clonal dynamics and somatic evolution in mouse haematopoiesis, finding that stem cells accrue mutations at a rate similar to human progenitors and exhibit distinct age-related patterns.

This study develops cell type-specific aging clocks using single-cell transcriptomic data to quantify aging and rejuvenation in the brain's neurogenic regions.

The paper identifies cell type-specific chromatin loops anchored at large DNA methylation nadirs, revealing their role in stem and progenitor cell function.

This study shows that loss of Dnmt3a or MeCP2 in inhibitory neurons leads to distinct but overlapping neurological and molecular effects, with mCH playing a key role in Rett Syndrome pathogenesis.

This study examines DNA methylation changes during fibroblast-to-neuron reprogramming, identifying key factors and mechanisms involved in epigenomic remodeling.